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Fig. 1 | Military Medical Research

Fig. 1

From: Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

Fig. 1

Outline of single-cell sequencing applied to interrogate CAR-T cell biology in preclinical studies. Single-cell sequencing has been applied to interrogate CAR-T cell biology with in vitro and in vivo preclinical studies. a To discover promising TSAs; b To chart where the CAR-T vector integrates into the genome; c To unveil heterogeneities in the transcriptional, phenotypic, functional, and metabolic profiles of CAR-T cells; d Single-cell profiling of the behavior and phenotype of pre-infusion CAR-T cells; e Studying CAR-T cells in vivo and the cross-talk between CAR-T cells and TME. CAR chimeric antigen receptor, TSA tumor-specific antigens, TME tumor microenvironment

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Military Medical Research

ISSN: 2054-9369