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Table 1 Commonly used variables in SEER database

From: How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology

Type

Available variable

Cancer type

Description

Sociodemographics

Patient ID

NOS

Personal Identification Number

Age

NOS

Patient age at diagnosis

Sex

NOS

Gender in biological terms

Race/ethnicity

NOS

Physical traits and cultural identity

Year/Month of diagnosis

NOS

Month of diagnosis is excluded

Year of birth

NOS

NA

Marital status

NOS

Marital status at diagnosis

Insurance

NOS

Excluded since 2022

Census tract income

NOS

Median household income

Geographic location

Location

NOS

State-county at diagnosis; excluded since 2022

Registry

NOS

State of registry

Urban and rural distribution

NOS

Urban and rural areas

Socioeconomics

Socioeconomic status factors

NOS

22 county-level factors reported by American Community Survey County Attributes

Tumor

Site

NOS

ICD-O-3 topography code

Histology

NOS

ICD-O-3 morphology code

Sequence

NOS

Sequence of reported tumor

Biological characteristics

CNS

WHO grade, laterality, size

Non-CNS

Breast cancer subtype, etc. WHO grade, laterality, size

Biomarkers

CNS

IDH-mutant, 1p/19q co-deleted, H3K27M-mutant, SHH and p53 status, etc

Non-CNS

AFP, CA-125, CEA, hCG, PSA, etc. Vary by tumor site

Extent

NOS

Extension of the involvement; vary by tumor site

Metastasis

CNS

NA

Non-CNS

Brain/bone/lung/liver metastasis available after 2016

Stage

CNS

NA

Non-CNS

AJCC T/M/N staging and staging group

Lymph node status

CNS

NA

Non-CNS

Number of examined and positive regional nodes

Treatment

Surgery

NOS

Specifies if receiving the first course surgical treatment; operation type; extent of resection

Lymph node surgery

CNS

NA

Non-CNS

Number of regional lymph nodes removed

Radiotherapy

NOS

Specifies if receiving the first course of radiotherapy; radiotherapy type

Chemotherapy

NOS

Specifies if receiving the first course of chemotherapy

Outcomes

Status

NOS

Status at the last time reporting to the registry

Follow-up time

NOS

Survival time or follow-up time

  1. AFP alpha-fetoprotein, AJCC American Joint Committee on Cancer, CA-125 cancer antigen 125, CEA carcinoembryonic antigen, CNS central nervous system, hCG human chorionic gonadotrophin, H3K27M histone 3 lysine 27, ICD-O-3 International Classification of Diseases for Oncology, IDH isocitrate dehydrogenase, NOS not otherwise specified, NA not applicable, PSA prostate specific antigen, SHH sonic hedgehog, WHO World Health Organization